Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.
第一作者:
Brett L,Carlson
第一单位:
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.
作者:
主题词
动物(Animals);抗肿瘤药, 烷基化(Antineoplastic Agents, Alkylating);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);综合疗法(Combined Modality Therapy);达卡巴嗪(Dacarbazine);用药计划表(Drug Administration Schedule);基因, erbB-1(Genes, erbB-1);基因, p53(Genes, p53);胶质母细胞瘤(Glioblastoma);人类(Humans);甲基化(Methylation);小鼠(Mice);O(6)-甲基鸟嘌呤DNA甲基转移酶(O(6)-Methylguanine-DNA Methyltransferase);PTEN磷酸水解酶(PTEN Phosphohydrolase);辐射增敏药(Radiation-Sensitizing Agents);随机分配(Random Allocation);存活率分析(Survival Analysis);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.ijrobp.2009.04.026
PMID
19695438
发布时间
2025-05-29
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