IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17.
作者:
主题词
动物(Animals);消炎药(Anti-Inflammatory Agents);抗体, 单克隆(Antibodies, Monoclonal);骨髓细胞(Bone Marrow Cells);细胞黏附(Cell Adhesion);人类(Humans);整合素αVβ3(Integrin alphaVbeta3);白细胞介素17(Interleukin-17);白细胞, 单核(Leukocytes, Mononuclear);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);单核细胞(Monocytes);成骨细胞(Osteoblasts);破骨细胞(Osteoclasts);RANK配体(RANK Ligand);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1002/jcb.22326
PMID
19728295
发布时间
2017-11-16
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