换一批HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.
第一作者：
Jeffrey,Ward
第一单位：
Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, United States of America.
作者：
医学主题词
CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞周期蛋白质类(Cell Cycle Proteins);CULLIN蛋白质类(Cullin Proteins);DNA损伤(DNA Damage);流式细胞术(Flow Cytometry);GPI连接蛋白质类(GPI-Linked Proteins);基因表达(Gene Expression);基因表达调控, 病毒(Gene Expression Regulation, Viral);基因产物, vpr(Gene Products, vpr);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);杀伤细胞, 天然(Killer Cells, Natural);膜蛋白质类(Membrane Proteins);NK细胞凝集素样受体亚家族K(NK Cell Lectin-Like Receptor Subfamily K);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);干细胞(Stem Cells);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1371/journal.ppat.1000613
PMID
19798433
发布时间
2026-05-02
- 浏览69
PLoS pathogens
e1000613页
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