换一批FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
第一作者：
E Eroume A,Egom
第一单位：
Cardiovascular Research Group, School of Clinical and Laboratory Sciences, The University of Manchester, Manchester M13 9NT, UK.
作者：
医学主题词
动物(Animals);动物, 新生(Animals, Newborn);心律失常, 心性(Arrhythmias, Cardiac);疾病模型, 动物(Disease Models, Animal);酶激活(Enzyme Activation);基因表达调控(Gene Expression Regulation);细胞内间隙(Intracellular Space);男(雄)性(Male);百白咳毒素(Pertussis Toxin);磷酰化(Phosphorylation);丙二醇类(Propylene Glycols);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA, 信使(RNA, Messenger);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, 鞘磷脂(Receptors, Lysosphingolipid);再灌注损伤(Reperfusion Injury);信号传导(Signal Transduction);窦房结(Sinoatrial Node);鞘氨醇(Sphingosine);时间因素(Time Factors);超声检查(Ultrasonography);p21活化激酶类(p21-Activated Kinases)
DOI
10.1016/j.yjmcc.2009.10.009
PMID
19852968
发布时间
2025-05-29
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