换一批Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
第一作者：
Yunsong,Tong
第一单位：
Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. yunsong.tong@abbott.com
作者：
医学主题词
投药, 口服(Administration, Oral);动物(Animals);抗肿瘤药(Antineoplastic Agents);抗肿瘤药, 烷基化(Antineoplastic Agents, Alkylating);苯咪唑类(Benzimidazoles);生物利用度(Biological Availability);细胞系, 肿瘤(Cell Line, Tumor);达卡巴嗪(Dacarbazine);药物协同作用(Drug Synergism);女(雌)性(Female);人类(Humans);男(雄)性(Male);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肿瘤移植(Neoplasm Transplantation);恶二唑类(Oxadiazoles);吡啶类(Pyridines);构效关系(Structure-Activity Relationship);移植, 异种(Transplantation, Heterologous)
DOI
10.1021/jm900697r
PMID
19888760
发布时间
2018-12-01
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