Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.
第一作者:
Lucie,Tosca
第一单位:
Unité de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique (INRA), UMR85, F-37 380 Nouzilly, France Unité de Recherches Avicoles, INRA, URA83, F-37 380 Nouzilly, France.
作者:
医学主题词
AMP活化蛋白激酶类(AMP-Activated Protein Kinases);动物(Animals);牛(Cattle);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);细胞周期蛋白D2(Cyclin D2);细胞周期蛋白E(Cyclin E);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);减量调节(Down-Regulation);女(雌)性(Female);致育药, 女用(Fertility Agents, Female);粒层细胞(Granulosa Cells);人类(Humans);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);二甲双胍(Metformin);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);突变(Mutation);磷酰化(Phosphorylation);蛋白质生物合成(Protein Biosynthesis);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);重组蛋白质类(Recombinant Proteins);核糖体蛋白质S6激酶类, 70-kDa(Ribosomal Protein S6 Kinases, 70-kDa);核糖体蛋白质S6激酶类, 90-kDa(Ribosomal Protein S6 Kinases, 90-kDa);信号传导(Signal Transduction);转染(Transfection)
DOI
10.1530/REP-09-0351
PMID
19906888
发布时间
2017-11-16
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