换一批Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
第一作者：
Mark E,Schnute
第一单位：
Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
作者：
医学主题词
投药, 口服(Administration, Oral);动物(Animals);结合部位(Binding Sites);软骨(Cartilage);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);疾病模型, 动物(Disease Models, Animal);药物发现(Drug Discovery);基质金属蛋白酶13(Matrix Metalloproteinase 13);骨关节炎(Osteoarthritis);吡啶羧酸类(Picolinic Acids);蛋白酶抑制药(Protease Inhibitors);大鼠(Rats);四唑类(Tetrazoles);锌(Zinc)
DOI
10.1016/j.bmcl.2009.11.081
PMID
20005097
发布时间
2013-11-21
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