Glimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.
第一作者:
Clive,Bate
第一单位:
Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, United Kingdom. cbate@rvc.ac.uk
作者:
主题词
4-氯汞苯磺酸盐(4-Chloromercuribenzenesulfonate);动物(Animals);细胞系(Cell Line);细胞膜(Cell Membrane);细胞保护(Cytoprotection);酶激活(Enzyme Activation);糖基磷脂酰肌醇二酰甘油裂合酶(Glycosylphosphatidylinositol Diacylglycerol-Lyase);Ⅳ型磷脂酶A2(Group IV Phospholipases A2);人类(Humans);小鼠(Mice);神经元(Neurons);神经毒素类(Neurotoxins);肽类(Peptides);PrPC蛋白质类(PrPC Proteins);PrPSc蛋白质类(PrPSc Proteins);蛋白质结合(Protein Binding);磺酰脲化合物(Sulfonylurea Compounds)
DOI
10.1371/journal.pone.0008221
PMID
20011040
发布时间
2021-10-20
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PloS one
e8221页
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