Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.
第一作者:
Sarah A,Martin
第一单位:
Cancer Research UK Gene Function and Regulation Group, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
作者:
医学主题词
抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);抗氧化剂(Antioxidants);碱基序列(Base Sequence);细胞系, 肿瘤(Cell Line, Tumor);DNA损伤(DNA Damage);DNA错配修复(DNA Mismatch Repair);叶酸(Folic Acid);基因缺失(Gene Deletion);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);甲氨蝶呤(Methotrexate);分子序列数据(Molecular Sequence Data);MutS同源蛋白2(MutS Homolog 2 Protein);肿瘤(Neoplasms);氧化还原(Oxidation-Reduction);RNA, 反义(RNA, Antisense)
DOI
10.1002/emmm.200900040
PMID
20049736
发布时间
2025-05-29
- 浏览5
EMBO molecular medicine
323-37页
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