DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.

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作者： Boris,Novakovic ^[1] ; Nick C,Wong ^[2] ; Mandy,Sibson ^[2] ; Hong-Kiat,Ng ^[2] ; Ruth,Morley ^[2] ; Ursula,Manuelpillai ^[3] ; Thomas,Down ^[4] ; Vardhman K,Rakyan ^[5] ; Stephan,Beck ^[6] ; Stefan,Hiendleder ^[7] ; Claire T,Roberts ^[8] ; Jeffrey M,Craig ^[1] ; Richard,Saffery ^[9]

作者单位： Developmental Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia. ^[1] Developmental Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia. ^[2] Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia. ^[3] Wellcome Trust Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom. ^[4] Institute of Cell and Molecular Science, Barts and the London, London E1 2AT, United Kingdom. ^[5] University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom. ^[6] JS Davies Epigenetics and Genetics Group, Animal Science, Adelaide, South Australia 5005, Australia. ^[7] School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia. ^[8] Developmental Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: richard.saffery@mcri.edu.au. ^[9]