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Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

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第一作者： Christopher S,Ward

第一单位： Department of Radiology and Biomedical Imaging , University of California at San Francisco, San Francisco, California 94158, USA.

作者： Christopher S,Ward ^[1] ; Humsa S,Venkatesh ; Myriam M,Chaumeil ; Alissa H,Brandes ; Mark,Vancriekinge ; Hagit,Dafni ; Subramaniam,Sukumar ; Sarah J,Nelson ; Daniel B,Vigneron ; John,Kurhanewicz ; C David,James ; Daphne A,Haas-Kogan ; Sabrina M,Ronen

作者单位： Department of Radiology and Biomedical Imaging , University of California at San Francisco, San Francisco, California 94158, USA. ^[1]

医学主题词动物(Animals);碳同位素(Carbon Isotopes);色酮类(Chromones);药物释放系统(Drug Delivery Systems);酶抑制剂(Enzyme Inhibitors);胶质母细胞瘤(Glioblastoma);人类(Humans);乳酸(Lactic Acid);磁共振波谱学(Magnetic Resonance Spectroscopy);小鼠(Mice);小鼠, 裸(Mice, Nude);监测, 生理学(Monitoring, Physiologic);吗啉类(Morpholines);肿瘤(Neoplasms);西罗莫司(Sirolimus);治疗结果(Treatment Outcome);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/0008-5472.CAN-09-2251

PMID 20145128

发布时间 2025-05-29

基金项目

R21 CA120010-03/CA/NCI NIH HHS/United States R01 CA130819-02/CA/NCI NIH HHS/United States P50 CA097257-05/CA/NCI NIH HHS/United States UL1 RR024131/RR/NCRR NIH HHS/United States R01 CA130819/CA/NCI NIH HHS/United States P50 CA097257/CA/NCI NIH HHS/United States R21 CA120010-01A1/CA/NCI NIH HHS/United States CA097257/CA/NCI NIH HHS/United States R21 CA120010/CA/NCI NIH HHS/United States UL1 RR024131-01/RR/NCRR NIH HHS/United States

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