Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential.

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作者： H Garry,Dallmann ^[1] ; Oliver J,Fackelmayer ; Guy,Tomer ; Joe,Chen ; Anna,Wiktor-Becker ; Tracey,Ferrara ; Casey,Pope ; Marcos T,Oliveira ; Peter M J,Burgers ; Laurie S,Kaguni ; Charles S,McHenry

作者单位： Department of Chemistry and Biochemistry, University of Colorado, Campus Box 215, Boulder, Colorado 80309, USA. ^[1]

主题词细菌(Bacteria);DNA复制(DNA Replication);DNA, 细菌(DNA, Bacterial);指导DNA的DNA聚合酶(DNA-Directed DNA Polymerase);药物评价, 临床前(Drug Evaluation, Preclinical);酶抑制剂(Enzyme Inhibitors);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);核酸合成抑制剂(Nucleic Acid Synthesis Inhibitors);小分子化合物库(Small Molecule Libraries);底物特异性(Substrate Specificity)

DOI 10.1021/bi9020764

PMID 20184361

发布时间 2021-10-20

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Biochemistry

2010年49卷11期

2551-62页

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Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential.

Biochemistry

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Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential.

Biochemistry

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Biochemistry

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