Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.
第一作者:
Jia-Ning,Fu
第一单位:
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
作者:
医学主题词
细胞分裂(Cell Division);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);顺铂(Cisplatin);结肠肿瘤(Colonic Neoplasms);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);药物协同作用(Drug Synergism);流式细胞术(Flow Cytometry);G1期(G1 Phase);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);模型, 生物学(Models, Biological);肿瘤蛋白质类(Neoplasm Proteins);有机硒化合物(Organoselenium Compounds);硫氧还蛋白二硫化物还原酶(Thioredoxin-Disulfide Reductase)
DOI
10.1007/s10637-010-9401-y
PMID
20195699
发布时间
2021-10-20
- 浏览83
Investigational new drugs
627-36页
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