换一批
换一批Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.
作者：
主题词
腺苷三磷酸(Adenosine Triphosphate);投药, 口服(Administration, Oral);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);药物评价, 临床前(Drug Evaluation, Preclinical);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);分子模拟(Molecular Mimicry);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质类(Proto-Oncogene Proteins);喹唑啉类(Quinazolines);构效关系(Structure-Activity Relationship);肿瘤负荷(Tumor Burden);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/jm901713n
PMID
20397705
发布时间
2023-12-13
- 浏览55
Journal of medicinal chemistry
3532-51页
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