The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21.
作者:
主题词
阿司匹林(Aspirin);印迹法, 蛋白质(Blotting, Western);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);环氧化酶1(Cyclooxygenase 1);缩肽类(Depsipeptides);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物协同作用(Drug Synergism);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);卵巢肿瘤(Ovarian Neoplasms);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);RNA干扰(RNA Interference);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)
DOI
10.4161/cbt.9.11.11873
PMID
20404564
发布时间
2021-10-20
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Cancer biology & therapy
928-35页
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