Towards consensus practices to qualify safety biomarkers for use in early drug development.

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作者： Frank D,Sistare ^[1] ; Frank,Dieterle ; Sean,Troth ; Daniel J,Holder ; David,Gerhold ; Dina,Andrews-Cleavenger ; William,Baer ; Graham,Betton ; Denise,Bounous ; Kevin,Carl ; Nathaniel,Collins ; Peter,Goering ; Federico,Goodsaid ; Yi-Zhong,Gu ; Valerie,Guilpin ; Ernie,Harpur ; Alita,Hassan ; David,Jacobson-Kram ; Peter,Kasper ; David,Laurie ; Beatriz Silva,Lima ; Romaldas,Maciulaitis ; William,Mattes ; Gérard,Maurer ; Leslie Ann,Obert ; Josef,Ozer ; Marisa,Papaluca-Amati ; Jonathan A,Phillips ; Mark,Pinches ; Matthew J,Schipper ; Karol L,Thompson ; Spiros,Vamvakas ; Jean-Marc,Vidal ; Jacky,Vonderscher ; Elizabeth,Walker ; Craig,Webb ; Yan,Yu

作者单位： Merck Research Laboratories, Safety Assessment, West Point, Pennsylvania, USA. frank_sistare@merck.com ^[1]

主题词动物(Animals);药物发现(Drug Discovery);人类(Humans);药用制剂(Pharmaceutical Preparations)

DOI 10.1038/nbt.1634

PMID 20458314

发布时间 2021-10-20

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