Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.
第一作者:
Mingxin,Tang
第一单位:
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark Street, Lee Medical Building, Vermillion, SD 57069, USA.
作者:
主题词
动物(Animals);硼酸化物(Boronic Acids);钙神经素(Calcineurin);细胞, 培养的(Cells, Cultured);结蛋白(Desmin);心力衰竭(Heart Failure);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);模型, 动物(Models, Animal);肌细胞, 心脏(Myocytes, Cardiac);NFATC转录因子类(NFATC Transcription Factors);蛋白酶抑制药(Protease Inhibitors);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);吡嗪类(Pyrazines);信号传导(Signal Transduction);应激, 生理学(Stress, Physiological)
DOI
10.1093/cvr/cvq217
PMID
20601385
发布时间
2021-10-20
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Cardiovascular research
424-33页
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