Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT.
作者:
主题词
苊类(Acenaphthenes);成年人(Adult);活组织检查(Biopsy);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);突变(Mutation);肿瘤(Neoplasms);磷酰化(Phosphorylation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);核糖核苷酸类(Ribonucleotides);治疗结果(Treatment Outcome)
DOI
10.1007/s10637-010-9479-2
PMID
20644979
发布时间
2021-10-20
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Investigational new drugs
1381-9页
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