A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

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作者： Dan,Xu ^[1] ; Siying,Wang ; Wen-Mei,Yu ; Gordon,Chan ; Toshiyuki,Araki ; Kevin D,Bunting ; Benjamin G,Neel ; Cheng-Kui,Qu

作者单位： Department of Medicine, Division of Hematology/Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. ^[1]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);细胞凋亡(Apoptosis);骨髓细胞(Bone Marrow Cells);骨髓移植(Bone Marrow Transplantation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);造血干细胞(Hematopoietic Stem Cells);白细胞介素3(Interleukin-3);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);突变(Mutation);骨髓增殖性疾病(Myeloproliferative Disorders);磷蛋白类(Phosphoproteins);蛋白质酪氨酸磷酸酶, 非受体11型(Protein Tyrosine Phosphatase, Non-Receptor Type 11)

DOI 10.1182/blood-2010-01-265652

PMID 20651068

发布时间 2021-10-20

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Blood

2010年116卷18期

3611-21页

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A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

Blood

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Blood

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A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

Blood

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Blood

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