An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
第一作者:
Michael A,Morse
第一单位:
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. morse004@mc.duke.edu
作者:
主题词
成年人(Adult);老年人(Aged);甲病毒属(Alphavirus);抗体, 中和(Antibodies, Neutralizing);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);抗原, 肿瘤(Antigens, Neoplasm);癌胚抗原(Carcinoembryonic Antigen);结直肠肿瘤(Colorectal Neoplasms);女(雌)性(Female);遗传载体(Genetic Vectors);人类(Humans);男(雄)性(Male);中年人(Middle Aged);肿瘤(Neoplasms);复制子(Replicon);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)
DOI
10.1172/JCI42672
PMID
20679728
发布时间
2021-10-20
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