换一批
换一批Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice.
作者：
关键词
6-NBDG, 6-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-6-deoxyglucoseA350, Alexa Fluor? 350A568, Alexa Fluor? 568APP, amyloid-β precursor proteinCx, connexinDCF, dichlorofluoresceinDMEM, Dulbecco's modified Eagle's mediumFBS, fetal bovine serumGFAP, glial fibrillary acidic proteinH2DCF-DA, carboxydihydrodichlorofluorescein diacetateL-LME, L-leucine methyl ester hydrochlorideROS, reactive oxygen speciesSR101, sulforhodamine 101STZ, streptozotocinaCSF, artificial cerebral spinal fluidamyloid proteinastrocyteconnexindBcAMP, dibutyryl cAMPdye transfergap junctionmetabolite trafficking
主题词
阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);星形细胞(Astrocytes);细胞间通讯(Cell Communication);细胞, 培养的(Cells, Cultured);女(雌)性(Female);缝隙接合部(Gap Junctions);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交DBA(Mice, Inbred DBA);小鼠, 转基因(Mice, Transgenic);神经网(Nerve Net);肽碎片(Peptide Fragments);大鼠(Rats);大鼠, Wistar(Rats, Wistar)
DOI
10.1042/AN20100017
PMID
20730033
发布时间
2021-10-20
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