Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.
第一作者:
Fei,Huang
第一单位:
Bristol-Myers Squibb Company, Princeton, NJ 08543, USA.
作者:
医学主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因剂量(Gene Dosage);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);人类(Humans);小鼠(Mice);吡唑类(Pyrazoles);受体, IGF1型(Receptor, IGF Type 1);受体, 血小板源生长因子α(Receptor, Platelet-Derived Growth Factor alpha);横纹肌肉瘤(Rhabdomyosarcoma);转染(Transfection);三嗪类(Triazines);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/0008-5472.CAN-10-0391
PMID
20807811
发布时间
2010-09-16
- 浏览4
Cancer research
7221-31页
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