换一批
换一批Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism.
第一作者：
Smitha V,Bava
第一单位：
Integrated Cancer Research Program, Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala-695014, India.
作者：
主题词
细胞周期(Cell Cycle);细胞存活(Cell Survival);姜黄素(Curcumin);细胞周期蛋白D1(Cyclin D1);环氧化酶2(Cyclooxygenase 2);减量调节(Down-Regulation);药物协同作用(Drug Synergism);酶激活(Enzyme Activation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);凋亡抑制蛋白质类(Inhibitor of Apoptosis Proteins);丝裂原激活蛋白激酶类(Mitogen-Activated Protein Kinases);模型, 生物学(Models, Biological);NF-κB(NF-kappa B);紫杉酚(Paclitaxel);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);信号传导(Signal Transduction);转录因子AP-1(Transcription Factor AP-1)
DOI
10.1016/j.biocel.2010.09.011
PMID
20883815
发布时间
2018-12-01
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