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首页> Nature genetics> Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

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第一作者： Elizabeth K,Speliotes
第一单位： Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
作者： Elizabeth K,Speliotes [1] ; Cristen J,Willer ; Sonja I,Berndt ; Keri L,Monda ; Gudmar,Thorleifsson ; Anne U,Jackson ; Hana,Lango Allen ; Cecilia M,Lindgren ; Jian'an,Luan ; Reedik,Mägi ; Joshua C,Randall ; Sailaja,Vedantam ; Thomas W,Winkler ; Lu,Qi ; Tsegaselassie,Workalemahu ; Iris M,Heid ; Valgerdur,Steinthorsdottir ; Heather M,Stringham ; Michael N,Weedon ; Eleanor,Wheeler ; Andrew R,Wood ; Teresa,Ferreira ; Robert J,Weyant ; Ayellet V,Segrè ; Karol,Estrada ; Liming,Liang ; James,Nemesh ; Ju-Hyun,Park ; Stefan,Gustafsson ; Tuomas O,Kilpeläinen ; Jian,Yang ; Nabila,Bouatia-Naji ; Tõnu,Esko ; Mary F,Feitosa ; Zoltán,Kutalik ; Massimo,Mangino ; Soumya,Raychaudhuri ; Andre,Scherag ; Albert Vernon,Smith ; Ryan,Welch ; Jing Hua,Zhao ; Katja K,Aben ; Devin M,Absher ; Najaf,Amin ; Anna L,Dixon ; Eva,Fisher ; Nicole L,Glazer ; Michael E,Goddard ; Nancy L,Heard-Costa ; Volker,Hoesel ; Jouke-Jan,Hottenga ; Asa,Johansson ; Toby,Johnson ; Shamika,Ketkar ; Claudia,Lamina ; Shengxu,Li ; Miriam F,Moffatt ; Richard H,Myers ; Narisu,Narisu ; John R B,Perry ; Marjolein J,Peters ; Michael,Preuss ; Samuli,Ripatti ; Fernando,Rivadeneira ; Camilla,Sandholt ; Laura J,Scott ; Nicholas J,Timpson ; Jonathan P,Tyrer ; Sophie,van Wingerden ; Richard M,Watanabe ; Charles C,White ; Fredrik,Wiklund ; Christina,Barlassina ; Daniel I,Chasman ; Matthew N,Cooper ; John-Olov,Jansson ; Robert W,Lawrence ; Niina,Pellikka ; Inga,Prokopenko ; Jianxin,Shi ; Elisabeth,Thiering ; Helene,Alavere ; Maria T S,Alibrandi ; Peter,Almgren ; Alice M,Arnold ; Thor,Aspelund ; Larry D,Atwood ; Beverley,Balkau ; Anthony J,Balmforth ; Amanda J,Bennett ; Yoav,Ben-Shlomo ; Richard N,Bergman ; Sven,Bergmann ; Heike,Biebermann ; Alexandra I F,Blakemore ; Tanja,Boes ; Lori L,Bonnycastle ; Stefan R,Bornstein ; Morris J,Brown ; Thomas A,Buchanan ; Fabio,Busonero ; Harry,Campbell ; Francesco P,Cappuccio ; Christine,Cavalcanti-Proença ; Yii-Der Ida,Chen ; Chih-Mei,Chen ; Peter S,Chines ; Robert,Clarke ; Lachlan,Coin ; John,Connell ; Ian N M,Day ; Martin,den Heijer ; Jubao,Duan ; Shah,Ebrahim ; Paul,Elliott ; Roberto,Elosua ; Gudny,Eiriksdottir ; Michael R,Erdos ; Johan G,Eriksson ; Maurizio F,Facheris ; Stephan B,Felix ; Pamela,Fischer-Posovszky ; Aaron R,Folsom ; Nele,Friedrich ; Nelson B,Freimer ; Mao,Fu ; Stefan,Gaget ; Pablo V,Gejman ; Eco J C,Geus ; Christian,Gieger ; Anette P,Gjesing ; Anuj,Goel ; Philippe,Goyette ; Harald,Grallert ; Jürgen,Grässler ; Danielle M,Greenawalt ; Christopher J,Groves ; Vilmundur,Gudnason ; Candace,Guiducci ; Anna-Liisa,Hartikainen ; Neelam,Hassanali ; Alistair S,Hall ; Aki S,Havulinna ; Caroline,Hayward ; Andrew C,Heath ; Christian,Hengstenberg ; Andrew A,Hicks ; Anke,Hinney ; Albert,Hofman ; Georg,Homuth ; Jennie,Hui ; Wilmar,Igl ; Carlos,Iribarren ; Bo,Isomaa ; Kevin B,Jacobs ; Ivonne,Jarick ; Elizabeth,Jewell ; Ulrich,John ; Torben,Jørgensen ; Pekka,Jousilahti ; Antti,Jula ; Marika,Kaakinen ; Eero,Kajantie ; Lee M,Kaplan ; Sekar,Kathiresan ; Johannes,Kettunen ; Leena,Kinnunen ; Joshua W,Knowles ; Ivana,Kolcic ; Inke R,König ; Seppo,Koskinen ; Peter,Kovacs ; Johanna,Kuusisto ; Peter,Kraft ; Kirsti,Kvaløy ; Jaana,Laitinen ; Olivier,Lantieri ; Chiara,Lanzani ; Lenore J,Launer ; Cecile,Lecoeur ; Terho,Lehtimäki ; Guillaume,Lettre ; Jianjun,Liu ; Marja-Liisa,Lokki ; Mattias,Lorentzon ; Robert N,Luben ; Barbara,Ludwig ; MAGIC ; Paolo,Manunta ; Diana,Marek ; Michel,Marre ; Nicholas G,Martin ; Wendy L,McArdle ; Anne,McCarthy ; Barbara,McKnight ; Thomas,Meitinger ; Olle,Melander ; David,Meyre ; Kristian,Midthjell ; Grant W,Montgomery ; Mario A,Morken ; Andrew P,Morris ; Rosanda,Mulic ; Julius S,Ngwa ; Mari,Nelis ; Matt J,Neville ; Dale R,Nyholt ; Christopher J,O'Donnell ; Stephen,O'Rahilly ; Ken K,Ong ; Ben,Oostra ; Guillaume,Paré ; Alex N,Parker ; Markus,Perola ; Irene,Pichler ; Kirsi H,Pietiläinen ; Carl G P,Platou ; Ozren,Polasek ; Anneli,Pouta ; Suzanne,Rafelt ; Olli,Raitakari ; Nigel W,Rayner ; Martin,Ridderstråle ; Winfried,Rief ; Aimo,Ruokonen ; Neil R,Robertson ; Peter,Rzehak ; Veikko,Salomaa ; Alan R,Sanders ; Manjinder S,Sandhu ; Serena,Sanna ; Jouko,Saramies ; Markku J,Savolainen ; Susann,Scherag ; Sabine,Schipf ; Stefan,Schreiber ; Heribert,Schunkert ; Kaisa,Silander ; Juha,Sinisalo ; David S,Siscovick ; Jan H,Smit ; Nicole,Soranzo ; Ulla,Sovio ; Jonathan,Stephens ; Ida,Surakka ; Amy J,Swift ; Mari-Liis,Tammesoo ; Jean-Claude,Tardif ; Maris,Teder-Laving ; Tanya M,Teslovich ; John R,Thompson ; Brian,Thomson ; Anke,Tönjes ; Tiinamaija,Tuomi ; Joyce B J,van Meurs ; Gert-Jan,van Ommen ; Vincent,Vatin ; Jorma,Viikari ; Sophie,Visvikis-Siest ; Veronique,Vitart ; Carla I G,Vogel ; Benjamin F,Voight ; Lindsay L,Waite ; Henri,Wallaschofski ; G Bragi,Walters ; Elisabeth,Widen ; Susanna,Wiegand ; Sarah H,Wild ; Gonneke,Willemsen ; Daniel R,Witte ; Jacqueline C,Witteman ; Jianfeng,Xu ; Qunyuan,Zhang ; Lina,Zgaga ; Andreas,Ziegler ; Paavo,Zitting ; John P,Beilby ; I Sadaf,Farooqi ; Johannes,Hebebrand ; Heikki V,Huikuri ; Alan L,James ; Mika,Kähönen ; Douglas F,Levinson ; Fabio,Macciardi ; Markku S,Nieminen ; Claes,Ohlsson ; Lyle J,Palmer ; Paul M,Ridker ; Michael,Stumvoll ; Jacques S,Beckmann ; Heiner,Boeing ; Eric,Boerwinkle ; Dorret I,Boomsma ; Mark J,Caulfield ; Stephen J,Chanock ; Francis S,Collins ; L Adrienne,Cupples ; George Davey,Smith ; Jeanette,Erdmann ; Philippe,Froguel ; Henrik,Grönberg ; Ulf,Gyllensten ; Per,Hall ; Torben,Hansen ; Tamara B,Harris ; Andrew T,Hattersley ; Richard B,Hayes ; Joachim,Heinrich ; Frank B,Hu ; Kristian,Hveem ; Thomas,Illig ; Marjo-Riitta,Jarvelin ; Jaakko,Kaprio ; Fredrik,Karpe ; Kay-Tee,Khaw ; Lambertus A,Kiemeney ; Heiko,Krude ; Markku,Laakso ; Debbie A,Lawlor ; Andres,Metspalu ; Patricia B,Munroe ; Willem H,Ouwehand ; Oluf,Pedersen ; Brenda W,Penninx ; Annette,Peters ; Peter P,Pramstaller ; Thomas,Quertermous ; Thomas,Reinehr ; Aila,Rissanen ; Igor,Rudan ; Nilesh J,Samani ; Peter E H,Schwarz ; Alan R,Shuldiner ; Timothy D,Spector ; Jaakko,Tuomilehto ; Manuela,Uda ; André,Uitterlinden ; Timo T,Valle ; Martin,Wabitsch ; Gérard,Waeber ; Nicholas J,Wareham ; Hugh,Watkins ; Procardis Consortium ; James F,Wilson ; Alan F,Wright ; M Carola,Zillikens ; Nilanjan,Chatterjee ; Steven A,McCarroll ; Shaun,Purcell ; Eric E,Schadt ; Peter M,Visscher ; Themistocles L,Assimes ; Ingrid B,Borecki ; Panos,Deloukas ; Caroline S,Fox ; Leif C,Groop ; Talin,Haritunians ; David J,Hunter ; Robert C,Kaplan ; Karen L,Mohlke ; Jeffrey R,O'Connell ; Leena,Peltonen ; David,Schlessinger ; David P,Strachan ; Cornelia M,van Duijn ; H-Erich,Wichmann ; Timothy M,Frayling ; Unnur,Thorsteinsdottir ; Gonçalo R,Abecasis ; Inês,Barroso ; Michael,Boehnke ; Kari,Stefansson ; Kari E,North ; Mark I,McCarthy ; Joel N,Hirschhorn ; Erik,Ingelsson ; Ruth J F,Loos
作者单位： Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [1]
医学主题词 身高(Body Height);人体质量指数(Body Mass Index);身体测量(Body Size);体重(Body Weight);染色体图(Chromosome Mapping);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);肥胖症(Obesity);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI 10.1038/ng.686
PMID 20935630
发布时间 2025-05-29
基金项目
M01-RR00425/RR/NCRR NIH HHS/United States R01 MH061675/MH/NIMH NIH HHS/United States R01 CA050385/CA/NCI NIH HHS/United States 079895/WT_/Wellcome Trust/United Kingdom U01-HG004402/HG/NHGRI NIH HHS/United States R01-MH67257/MH/NIMH NIH HHS/United States CZB/4/710/CSO_/Chief Scientist Office/United Kingdom G9521010/MRC_/Medical Research Council/United Kingdom R01 DK073490/DK/NIDDK NIH HHS/United States R01-HL088119/HL/NHLBI NIH HHS/United States K23 DK080145/DK/NIDDK NIH HHS/United States N01 HC055016/HL/NHLBI NIH HHS/United States R01 MH063706/MH/NIMH NIH HHS/United States G0801056/MRC_/Medical Research Council/United Kingdom R01-MH61675/MH/NIMH NIH HHS/United States N01 HC085080/HL/NHLBI NIH HHS/United States R01 AA007535/AA/NIAAA NIH HHS/United States R01 DK058845/DK/NIDDK NIH HHS/United States MH084698/MH/NIMH NIH HHS/United States R01-MH60870/MH/NIMH NIH HHS/United States R56 DK062370/DK/NIDDK NIH HHS/United States N01-HC15103/HC/NHLBI NIH HHS/United States R01-HL59367/HL/NHLBI NIH HHS/United States R01 AA014041/AA/NIAAA NIH HHS/United States K05 AA017688/AA/NIAAA NIH HHS/United States N01 AG012100/AG/NIA NIH HHS/United States R01 MH084698/MH/NIMH NIH HHS/United States N01 HC055019/HL/NHLBI NIH HHS/United States G0600331/MRC_/Medical Research Council/United Kingdom N02-HL64278/HL/NHLBI NIH HHS/United States P30-DK072488/DK/NIDDK NIH HHS/United States 079557/WT_/Wellcome Trust/United Kingdom R01 HL087647/HL/NHLBI NIH HHS/United States Z01 HG000024/ImNIH/Intramural NIH HHS/United States U01 HL084729/HL/NHLBI NIH HHS/United States G0600705/MRC_/Medical Research Council/United Kingdom N01-HC85086/HC/NHLBI NIH HHS/United States R01-MH59571/MH/NIMH NIH HHS/United States AA13320/AA/NIAAA NIH HHS/United States R01-HL087676/HL/NHLBI NIH HHS/United States P01 CA087969/CA/NCI NIH HHS/United States R01 HL087679/HL/NHLBI NIH HHS/United States UL1 RR025005/RR/NCRR NIH HHS/United States N01 HG065403/HG/NHGRI NIH HHS/United States R01-MH79470/MH/NIMH NIH HHS/United States N01-HC85079/HC/NHLBI NIH HHS/United States R01-MH59586/MH/NIMH NIH HHS/United States G0000934/MRC_/Medical Research Council/United Kingdom R01-MH59160/MH/NIMH NIH HHS/United States U01 HL080295/HL/NHLBI NIH HHS/United States RL1-MH083268/MH/NIMH NIH HHS/United States R01 CA067262/CA/NCI NIH HHS/United States N01-HC85083/HC/NHLBI NIH HHS/United States N01 HC085082/HL/NHLBI NIH HHS/United States R01 HG002651/HG/NHGRI NIH HHS/United States BHF_/British Heart Foundation/United Kingdom R01 HL087676/HL/NHLBI NIH HHS/United States N02 HL064278/HL/NHLBI NIH HHS/United States U01-HL080295/HL/NHLBI NIH HHS/United States N01-HC55222/HC/NHLBI NIH HHS/United States R01 HL059367/HL/NHLBI NIH HHS/United States 075491/WT_/Wellcome Trust/United Kingdom N01 HC055021/HL/NHLBI NIH HHS/United States R01-MH60879/MH/NIMH NIH HHS/United States 083270/WT_/Wellcome Trust/United Kingdom 072960/WT_/Wellcome Trust/United Kingdom MC_U127561128/MRC_/Medical Research Council/United Kingdom DA12854/DA/NIDA NIH HHS/United States N01-HC75150/HC/NHLBI NIH HHS/United States 068545/WT_/Wellcome Trust/United Kingdom N01 HC085086/HL/NHLBI NIH HHS/United States N01-HC55015/HC/NHLBI NIH HHS/United States R01-MH59588/MH/NIMH NIH HHS/United States N01 HC085083/HL/NHLBI NIH HHS/United States R01-MH63706/MH/NIMH NIH HHS/United States R01-MH59565/MH/NIMH NIH HHS/United States AA13321/AA/NIAAA NIH HHS/United States AA10248/AA/NIAAA NIH HHS/United States K99-HL094535/HL/NHLBI NIH HHS/United States R01-HL086694/HL/NHLBI NIH HHS/United States R01 DK072193/DK/NIDDK NIH HHS/United States CA87969/CA/NCI NIH HHS/United States R01 HL086694/HL/NHLBI NIH HHS/United States DK58845/DK/NIDDK NIH HHS/United States R01-HL087647/HL/NHLBI NIH HHS/United States R01 DK068336/DK/NIDDK NIH HHS/United States N01 HC085085/HC/NHLBI NIH HHS/United States U01 MH079469/MH/NIMH NIH HHS/United States DH_/Department of Health/United Kingdom R01 AA013326/AA/NIAAA NIH HHS/United States N01 HC055015/HL/NHLBI NIH HHS/United States T32 HG000040/HG/NHGRI NIH HHS/United States U01-GM074518/GM/NIGMS NIH HHS/United States R56 DA012854/DA/NIDA NIH HHS/United States R01 HL087652/HL/NHLBI NIH HHS/United States F32 DK079466/DK/NIDDK NIH HHS/United States U01 HG004402/HG/NHGRI NIH HHS/United States N01-HC55022/HC/NHLBI NIH HHS/United States CA49449/CA/NCI NIH HHS/United States 076113/WT_/Wellcome Trust/United Kingdom HG002651/HG/NHGRI NIH HHS/United States R01 DK075787/DK/NIDDK NIH HHS/United States MC_U137686857/MRC_/Medical Research Council/United Kingdom U01 CA067262/CA/NCI NIH HHS/United States R01-DK075787/DK/NIDDK NIH HHS/United States R01 DK075681/DK/NIDDK NIH HHS/United States R01 CA065725/CA/NCI NIH HHS/United States R01-HL087641/HL/NHLBI NIH HHS/United States R01-HL087652/HL/NHLBI NIH HHS/United States CA67262/CA/NCI NIH HHS/United States R01 DK062370/DK/NIDDK NIH HHS/United States N01-HC55019/HC/NHLBI NIH HHS/United States R01 MH067257/MH/NIMH NIH HHS/United States R01 AA013321/AA/NIAAA NIH HHS/United States K99 HL094535/HL/NHLBI NIH HHS/United States R01 MH060870/MH/NIMH NIH HHS/United States R01 MH081800/MH/NIMH NIH HHS/United States CA047988/CA/NCI NIH HHS/United States U01 HL084756/HL/NHLBI NIH HHS/United States HL084729/HL/NHLBI NIH HHS/United States P30 DK046200/DK/NIDDK NIH HHS/United States N01 HC055020/HL/NHLBI NIH HHS/United States N01-HC85082/HC/NHLBI NIH HHS/United States DK072193/DK/NIDDK NIH HHS/United States MC_U106179471/MRC_/Medical Research Council/United Kingdom U01-HG004399/HG/NHGRI NIH HHS/United States U01 DK062418/DK/NIDDK NIH HHS/United States P30 DK063491/DK/NIDDK NIH HHS/United States R01 MH059571/MH/NIMH NIH HHS/United States R01 MH059565/MH/NIMH NIH HHS/United States HL71981/HL/NHLBI NIH HHS/United States P30 DK072488/DK/NIDDK NIH HHS/United States Z01-HG000024/HG/NHGRI NIH HHS/United States N01 HC025195/HL/NHLBI NIH HHS/United States MC_U106179472/MRC_/Medical Research Council/United Kingdom R01DK068336/DK/NIDDK NIH HHS/United States R01-DK073490/DK/NIDDK NIH 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States R01-MH59566/MH/NIMH NIH HHS/United States U01 CA098233/CA/NCI NIH HHS/United States AA014041/AA/NIAAA NIH HHS/United States U54-RR020278/RR/NCRR NIH HHS/United States R01 HL071981/HL/NHLBI NIH HHS/United States N01 HC055018/HL/NHLBI NIH HHS/United States R01 CA047988/CA/NCI NIH HHS/United States R01-HL087700/HL/NHLBI NIH HHS/United States M01 RR000425/RR/NCRR NIH HHS/United States 064890/WT_/Wellcome Trust/United Kingdom N01-N01HC-55021/HC/NHLBI NIH HHS/United States U01 DK062370/DK/NIDDK NIH HHS/United States G9824984/MRC_/Medical Research Council/United Kingdom N01 HC085084/HC/NHLBI NIH HHS/United States DK062370/DK/NIDDK NIH HHS/United States 077016/WT_/Wellcome Trust/United Kingdom N01-HC85085/HC/NHLBI NIH HHS/United States N01-HC85080/HC/NHLBI NIH HHS/United States T32-HG00040/HG/NHGRI NIH HHS/United States DK063491/DK/NIDDK NIH HHS/United States R01 MH059566/MH/NIMH NIH HHS/United States N01 HC055022/HL/NHLBI NIH HHS/United States CA50385/CA/NCI NIH HHS/United States R01-MH79469/MH/NIMH NIH HHS/United States R01-HL087679/HL/NHLBI NIH HHS/United States N01-HC85084/HC/NHLBI NIH HHS/United States R01 CA049449/CA/NCI NIH HHS/United States RL1 MH083268/MH/NIMH NIH HHS/United States R01 MH059588/MH/NIMH NIH HHS/United States U01-CA098233/CA/NCI NIH HHS/United States N01-HC25195/HC/NHLBI NIH HHS/United States R01-MH81800/MH/NIMH NIH HHS/United States U01 CA049449/CA/NCI NIH HHS/United States N01 HC075150/HL/NHLBI NIH HHS/United States N01-HC55016/HC/NHLBI NIH HHS/United States R01 HL087641/HL/NHLBI NIH HHS/United States MC_QA137934/MRC_/Medical Research Council/United Kingdom K08 AR055688/AR/NIAMS NIH HHS/United States 085301/WT_/Wellcome Trust/United Kingdom MC_U106188470/MRC_/Medical Research Council/United Kingdom G0601261/MRC_/Medical Research Council/United Kingdom R01 HL087700/HL/NHLBI NIH HHS/United States U01 HG004399/HG/NHGRI NIH HHS/United States U01 GM074518/GM/NIGMS NIH HHS/United States U01-HL72515/HL/NHLBI NIH HHS/United States R01 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2010年42卷11期

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