换一批Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.
第一作者：
Seth W,Perry
第一单位：
Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. seth_perry@urmc.rochester.edu
作者：
医学主题词
艾滋病痴呆复合征(AIDS Dementia Complex);动物(Animals);印迹法, 蛋白质(Blotting, Western);卡配因(Calpain);细胞膜(Cell Membrane);细胞, 培养的(Cells, Cultured);多巴胺质膜转运蛋白质类(Dopamine Plasma Membrane Transport Proteins);酶激活(Enzyme Activation);糖原合成酶激酶3(Glycogen Synthase Kinase 3);动力学(Kinetics);中脑(Mesencephalon);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);显微镜检查, 荧光(Microscopy, Fluorescence);神经元(Neurons);PC12细胞(PC12 Cells);肽水解酶类(Peptide Hydrolases);蛋白酶抑制药(Protease Inhibitors);大鼠(Rats);兰尼碱受体钙释放通道(Ryanodine Receptor Calcium Release Channel);亚细胞部分(Subcellular Fractions);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)
DOI
10.1523/JNEUROSCI.1042-10.2010
PMID
20962236
发布时间
2025-05-29
- 浏览24
The Journal of neuroscience
14153-64页
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