Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.
第一作者:
Hideki,Kobayashi
第一单位:
Howard Hughes Medical Institute, Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
作者:
医学主题词
动物(Animals);细胞间通讯(Cell Communication);细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);内皮细胞(Endothelial Cells);酶激活(Enzyme Activation);血细胞生成(Hematopoiesis);造血干细胞(Hematopoietic Stem Cells);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);丝裂原激活蛋白激酶类(Mitogen-Activated Protein Kinases);旁分泌细胞细胞间通讯(Paracrine Communication);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);转化生长因子(Transforming Growth Factors)
DOI
10.1038/ncb2108
PMID
20972423
发布时间
2025-05-29
- 浏览17
Nature cell biology
1046-56页
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