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首页> Science (New York, N.Y.)> The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

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第一作者： International HIV Controllers Study
第一单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USA.
作者： International HIV Controllers Study [1] ; Florencia,Pereyra ; Xiaoming,Jia ; Paul J,McLaren ; Amalio,Telenti ; Paul I W,de Bakker ; Bruce D,Walker ; Stephan,Ripke ; Chanson J,Brumme ; Sara L,Pulit ; Mary,Carrington ; Carl M,Kadie ; Jonathan M,Carlson ; David,Heckerman ; Robert R,Graham ; Robert M,Plenge ; Steven G,Deeks ; Lauren,Gianniny ; Gabriel,Crawford ; Jordan,Sullivan ; Elena,Gonzalez ; Leela,Davies ; Amy,Camargo ; Jamie M,Moore ; Nicole,Beattie ; Supriya,Gupta ; Andrew,Crenshaw ; Noël P,Burtt ; Candace,Guiducci ; Namrata,Gupta ; Xiaojiang,Gao ; Ying,Qi ; Yuko,Yuki ; Alicja,Piechocka-Trocha ; Emily,Cutrell ; Rachel,Rosenberg ; Kristin L,Moss ; Paul,Lemay ; Jessica,O'Leary ; Todd,Schaefer ; Pranshu,Verma ; Ildiko,Toth ; Brian,Block ; Brett,Baker ; Alissa,Rothchild ; Jeffrey,Lian ; Jacqueline,Proudfoot ; Donna Marie L,Alvino ; Seanna,Vine ; Marylyn M,Addo ; Todd M,Allen ; Marcus,Altfeld ; Matthew R,Henn ; Sylvie,Le Gall ; Hendrik,Streeck ; David W,Haas ; Daniel R,Kuritzkes ; Gregory K,Robbins ; Robert W,Shafer ; Roy M,Gulick ; Cecilia M,Shikuma ; Richard,Haubrich ; Sharon,Riddler ; Paul E,Sax ; Eric S,Daar ; Heather J,Ribaudo ; Brian,Agan ; Shanu,Agarwal ; Richard L,Ahern ; Brady L,Allen ; Sherly,Altidor ; Eric L,Altschuler ; Sujata,Ambardar ; Kathryn,Anastos ; Ben,Anderson ; Val,Anderson ; Ushan,Andrady ; Diana,Antoniskis ; David,Bangsberg ; Daniel,Barbaro ; William,Barrie ; J,Bartczak ; Simon,Barton ; Patricia,Basden ; Nesli,Basgoz ; Suzane,Bazner ; Nicholaos C,Bellos ; Anne M,Benson ; Judith,Berger ; Nicole F,Bernard ; Annette M,Bernard ; Christopher,Birch ; Stanley J,Bodner ; Robert K,Bolan ; Emilie T,Boudreaux ; Meg,Bradley ; James F,Braun ; Jon E,Brndjar ; Stephen J,Brown ; Katherine,Brown ; Sheldon T,Brown ; Jedidiah,Burack ; Larry M,Bush ; Virginia,Cafaro ; Omobolaji,Campbell ; John,Campbell ; Robert H,Carlson ; J Kevin,Carmichael ; Kathleen K,Casey ; Chris,Cavacuiti ; Gregory,Celestin ; Steven T,Chambers ; Nancy,Chez ; Lisa M,Chirch ; Paul J,Cimoch ; Daniel,Cohen ; Lillian E,Cohn ; Brian,Conway ; David A,Cooper ; Brian,Cornelson ; David T,Cox ; Michael V,Cristofano ; George,Cuchural ; Julie L,Czartoski ; Joseph M,Dahman ; Jennifer S,Daly ; Benjamin T,Davis ; Kristine,Davis ; Sheila M,Davod ; Edwin,DeJesus ; Craig A,Dietz ; Eleanor,Dunham ; Michael E,Dunn ; Todd B,Ellerin ; Joseph J,Eron ; John J W,Fangman ; Claire E,Farel ; Helen,Ferlazzo ; Sarah,Fidler ; Anita,Fleenor-Ford ; Renee,Frankel ; Kenneth A,Freedberg ; Neel K,French ; Jonathan D,Fuchs ; Jon D,Fuller ; Jonna,Gaberman ; Joel E,Gallant ; Rajesh T,Gandhi ; Efrain,Garcia ; Donald,Garmon ; Joseph C,Gathe ; Cyril R,Gaultier ; Wondwoosen,Gebre ; Frank D,Gilman ; Ian,Gilson ; Paul A,Goepfert ; Michael S,Gottlieb ; Claudia,Goulston ; Richard K,Groger ; T Douglas,Gurley ; Stuart,Haber ; Robin,Hardwicke ; W David,Hardy ; P Richard,Harrigan ; Trevor N,Hawkins ; Sonya,Heath ; Frederick M,Hecht ; W Keith,Henry ; Melissa,Hladek ; Robert P,Hoffman ; James M,Horton ; Ricky K,Hsu ; Gregory D,Huhn ; Peter,Hunt ; Mark J,Hupert ; Mark L,Illeman ; Hans,Jaeger ; Robert M,Jellinger ; Mina,John ; Jennifer A,Johnson ; Kristin L,Johnson ; Heather,Johnson ; Kay,Johnson ; Jennifer,Joly ; Wilbert C,Jordan ; Carol A,Kauffman ; Homayoon,Khanlou ; Robert K,Killian ; Arthur Y,Kim ; David D,Kim ; Clifford A,Kinder ; Jeffrey T,Kirchner ; Laura,Kogelman ; Erna Milunka,Kojic ; P Todd,Korthuis ; Wayne,Kurisu ; Douglas S,Kwon ; Melissa,LaMar ; Harry,Lampiris ; Massimiliano,Lanzafame ; Michael M,Lederman ; David M,Lee ; Jean M L,Lee ; Marah J,Lee ; Edward T Y,Lee ; Janice,Lemoine ; Jay A,Levy ; Josep M,Llibre ; Michael A,Liguori ; Susan J,Little ; Anne Y,Liu ; Alvaro J,Lopez ; Mono R,Loutfy ; Dawn,Loy ; Debbie Y,Mohammed ; Alan,Man ; Michael K,Mansour ; Vincent C,Marconi ; Martin,Markowitz ; Rui,Marques ; Jeffrey N,Martin ; Harold L,Martin ; Kenneth Hugh,Mayer ; M Juliana,McElrath ; Theresa A,McGhee ; Barbara H,McGovern ; Katherine,McGowan ; Dawn,McIntyre ; Gavin X,Mcleod ; Prema,Menezes ; Greg,Mesa ; Craig E,Metroka ; Dirk,Meyer-Olson ; Andy O,Miller ; Kate,Montgomery ; Karam C,Mounzer ; Ellen H,Nagami ; Iris,Nagin ; Ronald G,Nahass ; Margret O,Nelson ; Craig,Nielsen ; David L,Norene ; David H,O'Connor ; Bisola O,Ojikutu ; Jason,Okulicz ; Olakunle O,Oladehin ; Edward C,Oldfield ; Susan A,Olender ; Mario,Ostrowski ; William F,Owen ; Eunice,Pae ; Jeffrey,Parsonnet ; Andrew M,Pavlatos ; Aaron M,Perlmutter ; Michael N,Pierce ; Jonathan M,Pincus ; Leandro,Pisani ; Lawrence Jay,Price ; Laurie,Proia ; Richard C,Prokesch ; Heather Calderon,Pujet ; Moti,Ramgopal ; Almas,Rathod ; Michael,Rausch ; J,Ravishankar ; Frank S,Rhame ; Constance Shamuyarira,Richards ; Douglas D,Richman ; Berta,Rodes ; Milagros,Rodriguez ; Richard C,Rose ; Eric S,Rosenberg ; Daniel,Rosenthal ; Polly E,Ross ; David S,Rubin ; Elease,Rumbaugh ; Luis,Saenz ; Michelle R,Salvaggio ; William C,Sanchez ; Veeraf M,Sanjana ; Steven,Santiago ; Wolfgang,Schmidt ; Hanneke,Schuitemaker ; Philip M,Sestak ; Peter,Shalit ; William,Shay ; Vivian N,Shirvani ; Vanessa I,Silebi ; James M,Sizemore ; Paul R,Skolnik ; Marcia,Sokol-Anderson ; James M,Sosman ; Paul,Stabile ; Jack T,Stapleton ; Sheree,Starrett ; Francine,Stein ; Hans-Jurgen,Stellbrink ; F Lisa,Sterman ; Valerie E,Stone ; David R,Stone ; Giuseppe,Tambussi ; Randy A,Taplitz ; Ellen M,Tedaldi ; Amalio,Telenti ; William,Theisen ; Richard,Torres ; Lorraine,Tosiello ; Cecile,Tremblay ; Marc A,Tribble ; Phuong D,Trinh ; Alice,Tsao ; Peggy,Ueda ; Anthony,Vaccaro ; Emilia,Valadas ; Thanes J,Vanig ; Isabel,Vecino ; Vilma M,Vega ; Wenoah,Veikley ; Barbara H,Wade ; Charles,Walworth ; Chingchai,Wanidworanun ; Douglas J,Ward ; Daniel A,Warner ; Robert D,Weber ; Duncan,Webster ; Steve,Weis ; David A,Wheeler ; David J,White ; Ed,Wilkins ; Alan,Winston ; Clifford G,Wlodaver ; Angelique,van't Wout ; David P,Wright ; Otto O,Yang ; David L,Yurdin ; Brandon W,Zabukovic ; Kimon C,Zachary ; Beth,Zeeman ; Meng,Zhao
作者单位： Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Boston, MA, USA. [1]
医学主题词 等位基因(Alleles);氨基酸类(Amino Acids);抗原呈递(Antigen Presentation);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);队列研究(Cohort Studies);疾病恶化(Disease Progression);基因, MHCⅠ类(Genes, MHC Class I);全基因组关联研究(Genome-Wide Association Study);HIV抗原(HIV Antigens);HIV感染(HIV Infections);HIV长期存活者(HIV Long-Term Survivors);HIV-1(HIV-1);HLA-A抗原(HLA-A Antigens);HLA-B抗原(HLA-B Antigens);HLA-C抗原(HLA-C Antigens);单倍型(Haplotypes);人类(Humans);免疫, 先天(Immunity, Innate);Logistic模型(Logistic Models);模型, 分子(Models, Molecular);多态性, 单核苷酸(Polymorphism, Single Nucleotide);蛋白质构象(Protein Conformation);病毒载量(Viral Load)
DOI 10.1126/science.1195271
PMID 21051598
发布时间 2026-03-07
基金项目
UL1 RR024131/RR/NCRR NIH HHS/United States AI069450/AI/NIAID NIH HHS/United States U01 AI069477/AI/NIAID NIH HHS/United States U01 AI069502/AI/NIAID NIH HHS/United States U01 AI069513/AI/NIAID NIH HHS/United States AI68634/AI/NIAID NIH HHS/United States AI69467/AI/NIAID NIH HHS/United States UM1 AI069423/AI/NIAID NIH HHS/United States AI069415/AI/NIAID NIH HHS/United States U01 AI069474/AI/NIAID NIH HHS/United States T32 AI007061/AI/NIAID NIH HHS/United States AI069465/AI/NIAID NIH HHS/United States U01 AI069434/AI/NIAID NIH HHS/United States U01 MH085520/MH/NIMH NIH HHS/United States AI069556/AI/NIAID NIH HHS/United States UM1 AI069501/AI/NIAID NIH HHS/United States UM1 AI069472/AI/NIAID NIH HHS/United States U01 AI069467/AI/NIAID NIH HHS/United States U01 AI069423/AI/NIAID NIH HHS/United States UM1 AI069513/AI/NIAID NIH HHS/United States AI069419/AI/NIAID NIH HHS/United States AI069511/AI/NIAID NIH HHS/United States AI46370/AI/NIAID NIH HHS/United States AI077505/AI/NIAID NIH HHS/United States U01 AI027661/AI/NIAID NIH HHS/United States UM1 AI069424/AI/NIAID NIH HHS/United States R01 AI077505/AI/NIAID NIH HHS/United States R01 MH054907/MH/NIMH NIH HHS/United States U01 AI069465/AI/NIAID NIH HHS/United States UM1 AI069434/AI/NIAID NIH HHS/United States K24 AI064086/AI/NIAID NIH HHS/United States UM1 AI069432/AI/NIAID NIH HHS/United States AI069501/AI/NIAID NIH HHS/United States AI069532/AI/NIAID NIH HHS/United States AI069474/AI/NIAID NIH HHS/United States K24AI069994/AI/NIAID NIH HHS/United States AI069434/AI/NIAID NIH HHS/United States UM1 AI069495/AI/NIAID NIH HHS/United States U01 AI069484/AI/NIAID NIH HHS/United States UM1 AI069471/AI/NIAID NIH HHS/United States U01 AI069556/AI/NIAID NIH HHS/United States HHMI/Howard Hughes Medical Institute/United States UM1 AI069428/AI/NIAID NIH HHS/United States AI069513/AI/NIAID NIH HHS/United States AI069502/AI/NIAID NIH HHS/United States K24 AI069994/AI/NIAID NIH HHS/United States TL1 RR024978/RR/NCRR NIH HHS/United States U01 AI034835/AI/NIAID NIH HHS/United States AI069423/AI/NIAID NIH HHS/United States AI30914/AI/NIAID NIH HHS/United States U01 AI069428/AI/NIAID NIH HHS/United States KL2 RR024977/RR/NCRR NIH HHS/United States U01 AI069532/AI/NIAID NIH HHS/United States K24 AI051966/AI/NIAID NIH HHS/United States UM1 AI069415/AI/NIAID NIH HHS/United States AI030914/AI/NIAID NIH HHS/United States AI27661/AI/NIAID NIH HHS/United States UM1 AI069484/AI/NIAID NIH HHS/United States AI069428/AI/NIAID NIH HHS/United States AI34853/AI/NIAID NIH HHS/United States UM1 AI068634/AI/NIAID NIH HHS/United States MH085520/MH/NIMH NIH HHS/United States U01 AI069501/AI/NIAID NIH HHS/United States R24 AI067039/AI/NIAID NIH HHS/United States P-30 AI27763/AI/NIAID NIH HHS/United States AI069452/AI/NIAID NIH HHS/United States AI069495/AI/NIAID NIH HHS/United States UM1 AI069477/AI/NIAID NIH HHS/United States U01 AI069432/AI/NIAID NIH HHS/United States P-30-AI060354/AI/NIAID NIH HHS/United States AI069484/AI/NIAID NIH HHS/United States AI068636/AI/NIAID NIH HHS/United States R01 AI087145/AI/NIAID NIH HHS/United States U01 AI069450/AI/NIAID NIH HHS/United States RR024975/RR/NCRR NIH HHS/United States U01 AI046370/AI/NIAID NIH HHS/United States U01 AI068636/AI/NIAID NIH HHS/United States UM1 AI069474/AI/NIAID NIH HHS/United States U01 AI034853/AI/NIAID NIH HHS/United States R37 AI028568/AI/NIAID NIH HHS/United States UM1 AI069452/AI/NIAID NIH HHS/United States AI069424/AI/NIAID NIH HHS/United States AI087145/AI/NIAID NIH HHS/United States UM1 AI069496/AI/NIAID NIH HHS/United States U01 AI069415/AI/NIAID NIH HHS/United States U01 AI069495/AI/NIAID NIH HHS/United States ImNIH/Intramural NIH HHS/United States UM1 AI069556/AI/NIAID NIH HHS/United States P30 AI027763/AI/NIAID NIH HHS/United States U01 AI069511/AI/NIAID NIH HHS/United States K23 DA019809/DA/NIDA NIH HHS/United States R01 MH071205/MH/NIMH NIH HHS/United States UM1 AI069502/AI/NIAID NIH HHS/United States U01 AI025859/AI/NIAID NIH HHS/United States UM1 AI069450/AI/NIAID NIH HHS/United States AI34835/AI/NIAID NIH HHS/United States MH071205/MH/NIMH NIH HHS/United States UM1 AI069532/AI/NIAID NIH HHS/United States UM1 AI069465/AI/NIAID NIH HHS/United States U01 AI069424/AI/NIAID NIH HHS/United States U01 AI032782/AI/NIAID NIH HHS/United States UL1 RR024975/RR/NCRR NIH HHS/United States HHSN261200800001C/RC/CCR NIH HHS/United States AI069472/AI/NIAID NIH HHS/United States UM1 AI069419/AI/NIAID NIH HHS/United States AI28568/AI/NIAID NIH HHS/United States AI069432/AI/NIAID NIH HHS/United States R01 AI028568/AI/NIAID NIH HHS/United States P30 AI060354/AI/NIAID NIH HHS/United States U01 AI069419/AI/NIAID NIH HHS/United States R01 AI030914/AI/NIAID NIH HHS/United States AI25859/AI/NIAID NIH HHS/United States UM1 AI069511/AI/NIAID NIH HHS/United States HHSN261200800001E/CA/NCI NIH HHS/United States U01 AI069452/AI/NIAID NIH HHS/United States UM1 AI069467/AI/NIAID NIH HHS/United States 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Science (New York, N.Y.)

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2010年330卷6010期

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