Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.-论文-万方医学网

第一作者： Mia M,Gaudet

第一单位： Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America.

作者： Mia M,Gaudet ^[1] ; Tomas,Kirchhoff ; Todd,Green ; Joseph,Vijai ; Joshua M,Korn ; Candace,Guiducci ; Ayellet V,Segrè ; Kate,McGee ; Lesley,McGuffog ; Christiana,Kartsonaki ; Jonathan,Morrison ; Sue,Healey ; Olga M,Sinilnikova ; Dominique,Stoppa-Lyonnet ; Sylvie,Mazoyer ; Marion,Gauthier-Villars ; Hagay,Sobol ; Michel,Longy ; Marc,Frenay ; GEMO Study Collaborators ; Frans B L,Hogervorst ; Matti A,Rookus ; J Margriet,Collée ; Nicoline,Hoogerbrugge ; Kees E P,van Roozendaal ; HEBON Study Collaborators ; Marion,Piedmonte ; Wendy,Rubinstein ; Stacy,Nerenstone ; Linda,Van Le ; Stephanie V,Blank ; Trinidad,Caldés ; Miguel,de la Hoya ; Heli,Nevanlinna ; Kristiina,Aittomäki ; Conxi,Lazaro ; Ignacio,Blanco ; Adalgeir,Arason ; Oskar T,Johannsson ; Rosa B,Barkardottir ; Peter,Devilee ; Olofunmilayo I,Olopade ; Susan L,Neuhausen ; Xianshu,Wang ; Zachary S,Fredericksen ; Paolo,Peterlongo ; Siranoush,Manoukian ; Monica,Barile ; Alessandra,Viel ; Paolo,Radice ; Catherine M,Phelan ; Steven,Narod ; Gad,Rennert ; Flavio,Lejbkowicz ; Anath,Flugelman ; Irene L,Andrulis ; Gord,Glendon ; Hilmi,Ozcelik ; OCGN ; Amanda E,Toland ; Marco,Montagna ; Emma,D'Andrea ; Eitan,Friedman ; Yael,Laitman ; Ake,Borg ; Mary,Beattie ; Susan J,Ramus ; Susan M,Domchek ; Katherine L,Nathanson ; Tim,Rebbeck ; Amanda B,Spurdle ; Xiaoqing,Chen ; Helene,Holland ; kConFab ; Esther M,John ; John L,Hopper ; Saundra S,Buys ; Mary B,Daly ; Melissa C,Southey ; Mary Beth,Terry ; Nadine,Tung ; Thomas V,Overeem Hansen ; Finn C,Nielsen ; Mark H,Greene ; Phuong L,Mai ; Ana,Osorio ; Mercedes,Durán ; Raquel,Andres ; Javier,Benítez ; Jeffrey N,Weitzel ; Judy,Garber ; Ute,Hamann ; EMBRACE ; Susan,Peock ; Margaret,Cook ; Clare,Oliver ; Debra,Frost ; Radka,Platte ; D Gareth,Evans ; Fiona,Lalloo ; Ros,Eeles ; Louise,Izatt ; Lisa,Walker ; Jacqueline,Eason ; Julian,Barwell ; Andrew K,Godwin ; Rita K,Schmutzler ; Barbara,Wappenschmidt ; Stefanie,Engert ; Norbert,Arnold ; Dorothea,Gadzicki ; Michael,Dean ; Bert,Gold ; Robert J,Klein ; Fergus J,Couch ; Georgia,Chenevix-Trench ; Douglas F,Easton ; Mark J,Daly ; Antonis C,Antoniou ; David M,Altshuler ; Kenneth,Offit

作者单位： Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America. ^[1]

医学主题词成年人(Adult);BRCA2蛋白质(BRCA2 Protein);乳腺肿瘤(Breast Neoplasms);染色体, 人, 10对(Chromosomes, Human, Pair 10);染色体, 人, 20对(Chromosomes, Human, Pair 20);DNA结合蛋白质类(DNA-Binding Proteins);女(雌)性(Female);基因频率(Gene Frequency);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);单倍型(Haplotypes);杂合子(Heterozygote);人类(Humans);连锁不平衡(Linkage Disequilibrium);中年人(Middle Aged);突变(Mutation);外显率(Penetrance);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 成纤维细胞生长因子, 2型(Receptor, Fibroblast Growth Factor, Type 2);危险因素(Risk Factors);转录因子(Transcription Factors)

DOI 10.1371/journal.pgen.1001183

PMID 21060860

发布时间 2025-05-29

基金项目

P20CA103694-3/CA/NCI NIH HHS/United States 11174/CRUK_/Cancer Research UK/United Kingdom 10118/CRUK_/Cancer Research UK/United Kingdom 11022/CRUK_/Cancer Research UK/United Kingdom P20 CA103694/CA/NCI NIH HHS/United States

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Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

PLoS genetics

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Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

PLoS genetics

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PLoS genetics

相关期刊

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