Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD.
第一作者:
Yushma,Bhurruth-Alcor
第一单位:
Imperial College Genetic Therapies Centre, Department of Chemistry, Flowers Building, Armstrong Road, Imperial College London, London, UK SW7 2AZ.
作者:
主题词
计算生物学(Computational Biology);糖尿病, 2型(Diabetes Mellitus, Type 2);吲哚类(Indoles);配体(Ligands);模型, 分子(Models, Molecular);分子结构(Molecular Structure);PPARα(PPAR alpha);PPARγ(PPAR gamma);软件(Software)
DOI
10.1039/c0ob00146e
PMID
21157612
发布时间
2017-11-16
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