Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages.
第一作者:
Hyo-Jin,An
第一单位:
Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
作者:
主题词
动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞培养技术(Cell Culture Techniques);细胞系(Cell Line);细胞存活(Cell Survival);环氧化酶2(Cyclooxygenase 2);剂量效应关系, 药物(Dose-Response Relationship, Drug);电泳迁移位移试验(Electrophoretic Mobility Shift Assay);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);小鼠(Mice);分子结构(Molecular Structure);NF-κB(NF-kappa B);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);植物根(Plant Roots);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);蔷薇科(Rosaceae);皂苷类(Saponins);信号传导(Signal Transduction);三萜类(Triterpenes);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.intimp.2011.01.002
PMID
21237302
发布时间
2011-03-18
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