Tissue transglutaminase-mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregation.
作者:
主题词
淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);CHO细胞(CHO Cells);色谱法, 液相(Chromatography, Liquid);圆二色性(Circular Dichroism);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);电泳, 聚丙烯酰氨凝胶(Electrophoresis, Polyacrylamide Gel);等电聚焦(Isoelectric Focusing);显微镜检查, 电子, 透射(Microscopy, Electron, Transmission);光谱法, 质量, 基质辅助激光解吸电离(Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization);串联质谱法(Tandem Mass Spectrometry);转谷酰胺酶(Transglutaminases)
DOI
10.1074/jbc.M110.176149
PMID
21300794
发布时间
2021-10-20
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