换一批Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
第一作者：
Ruiying,Zhao
第一单位：
Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
作者：
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);多蛋白复合物(Multiprotein Complexes);肽水解酶类(Peptide Hydrolases);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);信号传导(Signal Transduction);甲状腺(Thyroid Gland);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);增量调节(Up-Regulation)
DOI
10.1172/JCI44111
PMID
21317535
发布时间
2022-03-17
- 浏览37
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
