5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.
第一作者:
Fei,Shen
第一单位:
Department of Pharmacology, Theravance Inc., 901 Gateway Boulevard, South San Francisco, CA 94080, USA. fshen@theravance.com
作者:
主题词
淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);认知(Cognition);剂量效应关系, 药物(Dose-Response Relationship, Drug);豚鼠(Guinea Pigs);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);蛋白质结合(Protein Binding);蛋白质修饰, 转译(Protein Modification, Translational);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 血清素, 5-HT4(Receptors, Serotonin, 5-HT4);血清素5-HT4受体激动剂(Serotonin 5-HT4 Receptor Agonists)
DOI
10.1016/j.neuropharm.2011.02.026
PMID
21392515
发布时间
2011-05-31
- 浏览2
Neuropharmacology
69-79页
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