Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
作者:
主题词
别构调节(Allosteric Regulation);动物(Animals);结晶学, X线(Crystallography, X-Ray);酶激活(Enzyme Activation);GTP结合蛋白质α亚单位, G12-G13(GTP-Binding Protein alpha Subunits, G12-G13);鸟嘌呤核苷酸交换因子类(Guanine Nucleotide Exchange Factors);小鼠(Mice);多酶复合物(Multienzyme Complexes);突变(Mutation);蛋白质结构, 四级(Protein Structure, Quaternary);蛋白质结构, 三级(Protein Structure, Tertiary);构效关系(Structure-Activity Relationship)
DOI
10.1074/jbc.M110.201392
PMID
21507947
发布时间
2024-04-16
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