换一批Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.
第一作者：
Katsuya,Tanabe
第一单位：
Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.
作者：
医学主题词
转录激活因子3(Activating Transcription Factor 3);动物(Animals);细胞凋亡(Apoptosis);细胞系(Cell Line);内质网(Endoplasmic Reticulum);酶激活(Enzyme Activation);葡萄糖(Glucose);糖原合成酶激酶3(Glycogen Synthase Kinase 3);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);胰岛素分泌细胞(Insulin-Secreting Cells);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);棕榈酸(Palmitic Acid);信号传导(Signal Transduction);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1);应激, 生理学(Stress, Physiological)
DOI
10.1371/journal.pone.0018146
PMID
21541314
发布时间
2025-05-29
基金项目
P60 DK20579/DK/NIDDK NIH HHS/United States
R37 DK016746/DK/NIDDK NIH HHS/United States
R01 DK064938/DK/NIDDK NIH HHS/United States
R01 DK33301/DK/NIDDK NIH HHS/United States
R01 DK033301/DK/NIDDK NIH HHS/United States
R37 DK16746/DK/NIDDK NIH HHS/United States
R01 DK016746/DK/NIDDK NIH HHS/United States
R01 DK64938/DK/NIDDK NIH HHS/United States
R01 DK055267/DK/NIDDK NIH HHS/United States
P30 DK056341/DK/NIDDK NIH HHS/United States
P30DK056341/DK/NIDDK NIH HHS/United States
P60 DK020579/DK/NIDDK NIH HHS/United States
R01 DK073716/DK/NIDDK NIH HHS/United States
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