Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

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作者： Lawrence T,Bish ^[1] ; Meg M,Sleeper ; Caryn,Reynolds ; Jeffrey,Gazzara ; Elanor,Withnall ; Gretchen E,Singletary ; George,Buchlis ; Daniel,Hui ; Katherine A,High ; Guangping,Gao ; James M,Wilson ; H Lee,Sweeney

作者单位： Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. bish@mail.med.upenn.edu ^[1]

主题词动物(Animals);钙(Calcium);钙结合蛋白质类(Calcium-Binding Proteins);依赖病毒(Dependovirus);狗(Dogs);基因表达(Gene Expression);基因敲低技术(Gene Knockdown Techniques);基因转移技术(Gene Transfer Techniques);遗传载体(Genetic Vectors);单核细胞(Monocytes);肌细胞, 心脏(Myocytes, Cardiac);RNA, 信使(RNA, Messenger);RNA, 小分子干扰(RNA, Small Interfering);肌钙蛋白(Troponin)

DOI 10.1089/hum.2011.035

PMID 21542669

发布时间 2024-05-06

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Human gene therapy

2011年22卷8期

969-77页

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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

Human gene therapy

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Human gene therapy

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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

Human gene therapy

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Human gene therapy

相关期刊

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