Lysosomal accumulation of Trk protein in brain of GM₁ -gangliosidosis mouse and its restoration by chemical chaperone.
作者:
主题词
动物(Animals);动物, 新生(Animals, Newborn);印迹法, 蛋白质(Blotting, Western);脑(Brain);脑化学(Brain Chemistry);细胞, 培养的(Cells, Cultured);荧光抗体技术(Fluorescent Antibody Technique);神经节苷脂累积病, GM1型(Gangliosidosis, GM1);己糖胺类(Hexosamines);人类(Humans);免疫沉淀法(Immunoprecipitation);溶酶体(Lysosomes);膜微区(Membrane Microdomains);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);分子伴侣(Molecular Chaperones);神经生长因子类(Nerve Growth Factors);磷酰化(Phosphorylation);受体, trkA(Receptor, trkA);信号传导(Signal Transduction);β半乳糖苷酶类(beta-Galactosidase)
DOI
10.1111/j.1471-4159.2011.07310.x
PMID
21574998
发布时间
2011-07-13
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Journal of neurochemistry
399-406页
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