Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
第一作者:
Alan M,Hanash
第一单位:
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
作者:
主题词
动物(Animals);基因敲低技术(Gene Knockdown Techniques);移植物抗宿主病(Graft vs Host Disease);移植物白血病反应(Graft vs Leukemia Effect);人类(Humans);免疫, 先天(Immunity, Innate);白细胞介素21受体α亚单位(Interleukin-21 Receptor alpha Subunit);白细胞介素类(Interleukins);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交DBA(Mice, Inbred DBA);小鼠, 基因敲除(Mice, Knockout);器官特异性(Organ Specificity);信号传导(Signal Transduction);T淋巴细胞(T-Lymphocytes);组织供者(Tissue Donors);移植免疫学(Transplantation Immunology)
DOI
10.1182/blood-2010-07-294785
PMID
21596854
发布时间
2025-01-03
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Blood
446-55页
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