Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.
作者:
主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);动物(Animals);糖尿病(Diabetes Mellitus);电生理学(Electrophysiology);谷氨酸(Glutamic Acid);人类(Humans);高胰岛素血症(Hyperinsulinism);婴儿, 新生(Infant, Newborn);KATP通道(KATP Channels);男(雄)性(Male);诱变, 定点(Mutagenesis, Site-Directed);突变(Mutation);钾通道, 内向整流(Potassium Channels, Inwardly Rectifying);蛋白质结构, 三级(Protein Structure, Tertiary);大鼠(Rats);受体, 药物(Receptors, Drug);光滑爪蟾(Xenopus laevis)
DOI
10.2337/db10-1583
PMID
21617188
发布时间
2024-06-26
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Diabetes
1813-22页
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