Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor.
第一作者:
Ki-Young,Chang
第一单位:
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
作者:
医学主题词
年龄因素(Age Factors);动物(Animals);钙通道, T型(Calcium Channels, T-Type);小脑共济失调(Cerebellar Ataxia);小脑(Cerebellum);疾病模型, 动物(Disease Models, Animal);特发性震颤(Essential Tremor);人类(Humans);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);模型, 遗传学(Models, Genetic);运动活动(Motor Activity);浦肯野细胞(Purkinje Cells);受体, GABA-A(Receptors, GABA-A)
DOI
10.1016/j.bbrc.2011.05.082
PMID
21621520
发布时间
2021-10-20
基金项目
P01 GM047818/GM/NIGMS NIH HHS/United States
R01 AA013004/AA/NIAAA NIH HHS/United States
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