Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid.-论文-万方医学网

第一作者： Shiv K,Singh

第一单位： Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps-University of Marburg, D-35043 Marburg, Germany.

作者： Shiv K,Singh ^[1] ; Sandra,Baumgart ^[1] ; Garima,Singh ^[1] ; Alexander O,König ^[1] ; Kristina,Reutlinger ^[1] ; Lorenz C,Hofbauer ^[2] ; Peter,Barth ^[3] ; Thomas M,Gress ^[1] ; Gwen,Lomberk ^[4] ; Raul,Urrutia ^[4] ; Martin E,Fernandez-Zapico ^[5] ; Volker,Ellenrieder ^[6]

作者单位： Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps-University of Marburg, D-35043 Marburg, Germany. ^[1] Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University, D-01307 Dresden, Germany. ^[2] Department of Pathology, Philipps-University of Marburg, D-35043 Marburg, Germany. ^[3] Laboratory of Epigenetics and Chromatin Dynamics, Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, and. ^[4] Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55904. ^[5] Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps-University of Marburg, D-35043 Marburg, Germany,. Electronic address: ellenrie@med.uni-marburg.de. ^[6]

主题词主动转运, 细胞核(Active Transport, Cell Nucleus);动物(Animals);抗肿瘤药(Antineoplastic Agents);骨密度保护剂(Bone Density Conservation Agents);乳腺肿瘤(Breast Neoplasms);细胞核(Cell Nucleus);二膦酸盐类(Diphosphonates);女(雌)性(Female);糖原合成酶激酶3(Glycogen Synthase Kinase 3);人类(Humans);咪唑类(Imidazoles);小鼠(Mice);小鼠, 裸(Mice, Nude);NFATC转录因子类(NFATC Transcription Factors);肿瘤蛋白质类(Neoplasm Proteins);胰腺肿瘤(Pancreatic Neoplasms);磷酰化(Phosphorylation);蛋白质稳定性(Protein Stability);蛋白质结构, 三级(Protein Structure, Tertiary);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);信号传导(Signal Transduction);泛素化(Ubiquitination)

DOI 10.1074/jbc.M110.197533

PMID 21628454

发布时间 2021-10-20

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Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid.

The Journal of biological chemistry

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The Journal of biological chemistry

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Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid.

The Journal of biological chemistry

相似文献

The Journal of biological chemistry

相关期刊

检索历史清除