Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);癌, Lewis肺(Carcinoma, Lewis Lung);细胞系, 肿瘤(Cell Line, Tumor);内皮细胞(Endothelial Cells);更昔洛韦(Ganciclovir);基因表达(Gene Expression);黑色素瘤, 实验性(Melanoma, Experimental);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);原癌基因蛋白质类(Proto-Oncogene Proteins);重组蛋白质类(Recombinant Proteins);胸苷激酶(Thymidine Kinase);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.1084/jem.20100951
PMID
21646395
发布时间
2021-10-20
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