Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency.
第一作者:
Marija,Mihelec
第一单位:
Department of Genetics, University College London, Institute of Ophthalmology, London, United Kingdom.
作者:
主题词
方差分析(Analysis of Variance);动物(Animals);印迹法, 蛋白质(Blotting, Western);DNA引物(DNA Primers);依赖病毒(Dependovirus);剂量效应关系, 药物(Dose-Response Relationship, Drug);视网膜电描记术(Electroretinography);遗传载体(Genetic Vectors);鸟苷酸环化酶(Guanylate Cyclase);免疫组织化学(Immunohistochemistry);Leber先天性黑朦(Leber Congenital Amaurosis);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);光感受器细胞, 脊椎动物(Photoreceptor Cells, Vertebrate);受体, 细胞表面(Receptors, Cell Surface);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);视觉, 眼(Vision, Ocular)
DOI
10.1089/hum.2011.069
PMID
21671801
发布时间
2022-01-29
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Human gene therapy
1179-90页
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