Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations.
作者:
主题词
氨基糖苷类(Aminoglycosides);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);细胞死亡(Cell Death);细胞核(Cell Nucleus);细胞, 培养的(Cells, Cultured);密码子, 无义(Codon, Nonsense);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);庆大霉素类(Gentamicins);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);甲基-CpG-结合蛋白质2(Methyl-CpG-Binding Protein 2);RNA, 信使(RNA, Messenger);Rett综合征(Rett Syndrome)
DOI
10.1371/journal.pone.0020733
PMID
21695138
发布时间
2021-10-20
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