Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite.
第一作者:
Thomas,Seebeck
第一单位:
Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland. thomas.seebeck@izb.unibe.ch
作者:
主题词
1-甲基-3-异丁基黄嘌呤(1-Methyl-3-isobutylxanthine);氨基酸序列(Amino Acid Sequence);抗原虫药(Antiprotozoal Agents);结合部位(Binding Sites);催化域(Catalytic Domain);儿茶酚类(Catechols);人类(Humans);硕大利什曼原虫(Leishmania major);分子序列数据(Molecular Sequence Data);被忽略疾病(Neglected Diseases);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);序列比对(Sequence Alignment);布鲁斯锥虫布鲁斯亚种(Trypanosoma brucei brucei)
DOI
10.4155/fmc.11.77
PMID
21859303
发布时间
2024-04-10
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Future medicinal chemistry
1289-306页
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