换一批
换一批Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.
作者：
主题词
氨基酸取代(Amino Acid Substitution);动物(Animals);癌, 肾细胞(Carcinoma, Renal Cell);细胞分裂(Cell Division);细胞低氧(Cell Hypoxia);疾病模型, 动物(Disease Models, Animal);基因组不稳定性(Genomic Instability);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);肾疾病, 囊性(Kidney Diseases, Cystic);肾肿瘤(Kidney Neoplasms);肾小管, 近端(Kidney Tubules, Proximal);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);诱变, 定点(Mutagenesis, Site-Directed);新生血管化, 病理性(Neovascularization, Pathologic);启动区, 遗传(Promoter Regions, Genetic);重组融合蛋白质类(Recombinant Fusion Proteins);构效关系(Structure-Activity Relationship);增量调节(Up-Regulation);γ-谷氨酰转移酶(gamma-Glutamyltransferase);von Hippel-Lindau病(von Hippel-Lindau Disease)
DOI
10.1158/0008-5472.CAN-11-1745
PMID
21908555
发布时间
2022-02-08
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Cancer research
6848-56页
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