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首页> Nature> Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

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第一作者： International Consortium for Blood Pressure Genome-Wide Association Studies
作者： International Consortium for Blood Pressure Genome-Wide Association Studies ; Georg B,Ehret ; Patricia B,Munroe ; Kenneth M,Rice ; Murielle,Bochud ; Andrew D,Johnson ; Daniel I,Chasman ; Albert V,Smith ; Martin D,Tobin ; Germaine C,Verwoert ; Shih-Jen,Hwang ; Vasyl,Pihur ; Peter,Vollenweider ; Paul F,O'Reilly ; Najaf,Amin ; Jennifer L,Bragg-Gresham ; Alexander,Teumer ; Nicole L,Glazer ; Lenore,Launer ; Jing Hua,Zhao ; Yurii,Aulchenko ; Simon,Heath ; Siim,Sõber ; Afshin,Parsa ; Jian'an,Luan ; Pankaj,Arora ; Abbas,Dehghan ; Feng,Zhang ; Gavin,Lucas ; Andrew A,Hicks ; Anne U,Jackson ; John F,Peden ; Toshiko,Tanaka ; Sarah H,Wild ; Igor,Rudan ; Wilmar,Igl ; Yuri,Milaneschi ; Alex N,Parker ; Cristiano,Fava ; John C,Chambers ; Ervin R,Fox ; Meena,Kumari ; Min Jin,Go ; Pim,van der Harst ; Wen Hong Linda,Kao ; Marketa,Sjögren ; D G,Vinay ; Myriam,Alexander ; Yasuharu,Tabara ; Sue,Shaw-Hawkins ; Peter H,Whincup ; Yongmei,Liu ; Gang,Shi ; Johanna,Kuusisto ; Bamidele,Tayo ; Mark,Seielstad ; Xueling,Sim ; Khanh-Dung Hoang,Nguyen ; Terho,Lehtimäki ; Giuseppe,Matullo ; Ying,Wu ; Tom R,Gaunt ; N Charlotte,Onland-Moret ; Matthew N,Cooper ; Carl G P,Platou ; Elin,Org ; Rebecca,Hardy ; Santosh,Dahgam ; Jutta,Palmen ; Veronique,Vitart ; Peter S,Braund ; Tatiana,Kuznetsova ; Cuno S P M,Uiterwaal ; Adebowale,Adeyemo ; Walter,Palmas ; Harry,Campbell ; Barbara,Ludwig ; Maciej,Tomaszewski ; Ioanna,Tzoulaki ; Nicholette D,Palmer ; CARDIoGRAM consortium ; CKDGen Consortium ; KidneyGen Consortium ; EchoGen consortium ; CHARGE-HF consortium ; Thor,Aspelund ; Melissa,Garcia ; Yen-Pei C,Chang ; Jeffrey R,O'Connell ; Nanette I,Steinle ; Diederick E,Grobbee ; Dan E,Arking ; Sharon L,Kardia ; Alanna C,Morrison ; Dena,Hernandez ; Samer,Najjar ; Wendy L,McArdle ; David,Hadley ; Morris J,Brown ; John M,Connell ; Aroon D,Hingorani ; Ian N M,Day ; Debbie A,Lawlor ; John P,Beilby ; Robert W,Lawrence ; Robert,Clarke ; Jemma C,Hopewell ; Halit,Ongen ; Albert W,Dreisbach ; Yali,Li ; J Hunter,Young ; Joshua C,Bis ; Mika,Kähönen ; Jorma,Viikari ; Linda S,Adair ; Nanette R,Lee ; Ming-Huei,Chen ; Matthias,Olden ; Cristian,Pattaro ; Judith A Hoffman,Bolton ; Anna,Köttgen ; Sven,Bergmann ; Vincent,Mooser ; Nish,Chaturvedi ; Timothy M,Frayling ; Muhammad,Islam ; Tazeen H,Jafar ; Jeanette,Erdmann ; Smita R,Kulkarni ; Stefan R,Bornstein ; Jürgen,Grässler ; Leif,Groop ; Benjamin F,Voight ; Johannes,Kettunen ; Philip,Howard ; Andrew,Taylor ; Simonetta,Guarrera ; Fulvio,Ricceri ; Valur,Emilsson ; Andrew,Plump ; Inês,Barroso ; Kay-Tee,Khaw ; Alan B,Weder ; Steven C,Hunt ; Yan V,Sun ; Richard N,Bergman ; Francis S,Collins ; Lori L,Bonnycastle ; Laura J,Scott ; Heather M,Stringham ; Leena,Peltonen ; Markus,Perola ; Erkki,Vartiainen ; Stefan-Martin,Brand ; Jan A,Staessen ; Thomas J,Wang ; Paul R,Burton ; Maria,Soler Artigas ; Yanbin,Dong ; Harold,Snieder ; Xiaoling,Wang ; Haidong,Zhu ; Kurt K,Lohman ; Megan E,Rudock ; Susan R,Heckbert ; Nicholas L,Smith ; Kerri L,Wiggins ; Ayo,Doumatey ; Daniel,Shriner ; Gudrun,Veldre ; Margus,Viigimaa ; Sanjay,Kinra ; Dorairaj,Prabhakaran ; Vikal,Tripathy ; Carl D,Langefeld ; Annika,Rosengren ; Dag S,Thelle ; Anna Maria,Corsi ; Andrew,Singleton ; Terrence,Forrester ; Gina,Hilton ; Colin A,McKenzie ; Tunde,Salako ; Naoharu,Iwai ; Yoshikuni,Kita ; Toshio,Ogihara ; Takayoshi,Ohkubo ; Tomonori,Okamura ; Hirotsugu,Ueshima ; Satoshi,Umemura ; Susana,Eyheramendy ; Thomas,Meitinger ; H-Erich,Wichmann ; Yoon Shin,Cho ; Hyung-Lae,Kim ; Jong-Young,Lee ; James,Scott ; Joban S,Sehmi ; Weihua,Zhang ; Bo,Hedblad ; Peter,Nilsson ; George Davey,Smith ; Andrew,Wong ; Narisu,Narisu ; Alena,Stančáková ; Leslie J,Raffel ; Jie,Yao ; Sekar,Kathiresan ; Christopher J,O'Donnell ; Stephen M,Schwartz ; M Arfan,Ikram ; W T,Longstreth ; Thomas H,Mosley ; Sudha,Seshadri ; Nick R G,Shrine ; Louise V,Wain ; Mario A,Morken ; Amy J,Swift ; Jaana,Laitinen ; Inga,Prokopenko ; Paavo,Zitting ; Jackie A,Cooper ; Steve E,Humphries ; John,Danesh ; Asif,Rasheed ; Anuj,Goel ; Anders,Hamsten ; Hugh,Watkins ; Stephan J L,Bakker ; Wiek H,van Gilst ; Charles S,Janipalli ; K Radha,Mani ; Chittaranjan S,Yajnik ; Albert,Hofman ; Francesco U S,Mattace-Raso ; Ben A,Oostra ; Ayse,Demirkan ; Aaron,Isaacs ; Fernando,Rivadeneira ; Edward G,Lakatta ; Marco,Orru ; Angelo,Scuteri ; Mika,Ala-Korpela ; Antti J,Kangas ; Leo-Pekka,Lyytikäinen ; Pasi,Soininen ; Taru,Tukiainen ; Peter,Würtz ; Rick Twee-Hee,Ong ; Marcus,Dörr ; Heyo K,Kroemer ; Uwe,Völker ; Henry,Völzke ; Pilar,Galan ; Serge,Hercberg ; Mark,Lathrop ; Diana,Zelenika ; Panos,Deloukas ; Massimo,Mangino ; Tim D,Spector ; Guangju,Zhai ; James F,Meschia ; Michael A,Nalls ; Pankaj,Sharma ; Janos,Terzic ; M V Kranthi,Kumar ; Matthew,Denniff ; Ewa,Zukowska-Szczechowska ; Lynne E,Wagenknecht ; F Gerald R,Fowkes ; Fadi J,Charchar ; Peter E H,Schwarz ; Caroline,Hayward ; Xiuqing,Guo ; Charles,Rotimi ; Michiel L,Bots ; Eva,Brand ; Nilesh J,Samani ; Ozren,Polasek ; Philippa J,Talmud ; Fredrik,Nyberg ; Diana,Kuh ; Maris,Laan ; Kristian,Hveem ; Lyle J,Palmer ; Yvonne T,van der Schouw ; Juan P,Casas ; Karen L,Mohlke ; Paolo,Vineis ; Olli,Raitakari ; Santhi K,Ganesh ; Tien Y,Wong ; E Shyong,Tai ; Richard S,Cooper ; Markku,Laakso ; Dabeeru C,Rao ; Tamara B,Harris ; Richard W,Morris ; Anna F,Dominiczak ; Mika,Kivimaki ; Michael G,Marmot ; Tetsuro,Miki ; Danish,Saleheen ; Giriraj R,Chandak ; Josef,Coresh ; Gerjan,Navis ; Veikko,Salomaa ; Bok-Ghee,Han ; Xiaofeng,Zhu ; Jaspal S,Kooner ; Olle,Melander ; Paul M,Ridker ; Stefania,Bandinelli ; Ulf B,Gyllensten ; Alan F,Wright ; James F,Wilson ; Luigi,Ferrucci ; Martin,Farrall ; Jaakko,Tuomilehto ; Peter P,Pramstaller ; Roberto,Elosua ; Nicole,Soranzo ; Eric J G,Sijbrands ; David,Altshuler ; Ruth J F,Loos ; Alan R,Shuldiner ; Christian,Gieger ; Pierre,Meneton ; Andre G,Uitterlinden ; Nicholas J,Wareham ; Vilmundur,Gudnason ; Jerome I,Rotter ; Rainer,Rettig ; Manuela,Uda ; David P,Strachan ; Jacqueline C M,Witteman ; Anna-Liisa,Hartikainen ; Jacques S,Beckmann ; Eric,Boerwinkle ; Ramachandran S,Vasan ; Michael,Boehnke ; Martin G,Larson ; Marjo-Riitta,Järvelin ; Bruce M,Psaty ; Gonçalo R,Abecasis ; Aravinda,Chakravarti ; Paul,Elliott ; Cornelia M,van Duijn ; Christopher,Newton-Cheh ; Daniel,Levy ; Mark J,Caulfield ; Toby,Johnson
医学主题词 非洲(Africa);亚洲(Asia);血压(Blood Pressure);心血管疾病(Cardiovascular Diseases);冠状动脉疾病(Coronary Artery Disease);欧洲(Europe);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);高血压(Hypertension);肾疾病(Kidney Diseases);多态性, 单核苷酸(Polymorphism, Single Nucleotide);卒中(Stroke)
DOI 10.1038/nature10405
PMID 21909115
发布时间 2025-05-29
基金项目
R37HL051021/HL/NHLBI NIH HHS/United States M01-RR00425/RR/NCRR NIH HHS/United States RG/07/008/23674/BHF_/British Heart Foundation/United Kingdom UL1RR025005/RR/NCRR NIH HHS/United States DK078150/DK/NIDDK NIH HHS/United States N02-HL-6-4278/HL/NHLBI NIH HHS/United States G8802774/MRC_/Medical Research Council/United Kingdom N01-HC-25195/HC/NHLBI NIH HHS/United States U01HG004446/HG/NHGRI NIH HHS/United States N01 HC-95169/HC/NHLBI NIH HHS/United States 079895/WT_/Wellcome Trust/United Kingdom G19/35/MRC_/Medical Research Council/United Kingdom R01HL06094/HL/NHLBI NIH HHS/United States U01HG004726/HG/NHGRI NIH HHS/United States N01-HC-95162/HC/NHLBI NIH HHS/United States U01HG004438/HG/NHGRI NIH HHS/United States R01 HL088119/HL/NHLBI NIH HHS/United States 5R01HL08770002/HL/NHLBI NIH HHS/United States P30 ES010126/ES/NIEHS NIH HHS/United States MC_U137686857/MRC_/Medical Research Council/United Kingdom U01 NS069208-01/NS/NINDS NIH HHS/United States DK075787/DK/NIDDK NIH HHS/United States HL 54512/HL/NHLBI NIH HHS/United States R01 HL073410/HL/NHLBI NIH HHS/United States P01CA087969/CA/NCI NIH HHS/United States HL043851/HL/NHLBI NIH HHS/United States S06GM008016-380111/GM/NIGMS NIH HHS/United States G0501942/BHF_/British Heart Foundation/United Kingdom CZB/4/710/CSO_/Chief Scientist Office/United Kingdom R01 HL086694-04A1/HL/NHLBI NIH HHS/United States TW008288/TW/FIC NIH HHS/United States G0100222/MRC_/Medical Research Council/United Kingdom N01-HC-85085/HC/NHLBI NIH HHS/United States R01HL59367/HL/NHLBI NIH HHS/United States MC_UP_A100_1003/MRC_/Medical Research Council/United Kingdom U01 HL080295/HL/NHLBI NIH HHS/United States S06GM008016-320107/GM/NIGMS NIH HHS/United States U01HG004738/HG/NHGRI NIH HHS/United States RG/08/013/25942/BHF_/British Heart Foundation/United Kingdom P01CA055075/CA/NCI NIH HHS/United States RG/08/008/25291/BHF_/British Heart Foundation/United Kingdom SP/04/002/BHF_/British Heart Foundation/United Kingdom N01-AG-1-2109/AG/NIA NIH HHS/United States RG08/01/BHF_/British Heart Foundation/United Kingdom PG97012/BHF_/British Heart Foundation/United Kingdom R01HL060919/HL/NHLBI NIH HHS/United States SP/08/005/25115/BHF_/British Heart Foundation/United Kingdom N01-HC-85081/HC/NHLBI NIH HHS/United States U01HG004415/HG/NHGRI NIH HHS/United States U54 RR020278/RR/NCRR NIH HHS/United States U01HG004735/HG/NHGRI NIH HHS/United States 068545/Z/02/WT_/Wellcome Trust/United Kingdom N01-HC-55022/HC/NHLBI NIH HHS/United States K12RR023250/RR/NCRR NIH HHS/United States RR-024156/RR/NCRR NIH HHS/United States R01 CA094143/CA/NCI NIH HHS/United States G0801056/MRC_/Medical Research Council/United Kingdom R01HL061019/HL/NHLBI NIH HHS/United States N01-HC-55016/HC/NHLBI NIH HHS/United States N01-HC-95168/HC/NHLBI NIH HHS/United States 070191/Z/03/Z/WT_/Wellcome Trust/United Kingdom N01AG62101/AG/NIA NIH HHS/United States N01-HC-95163/HC/NHLBI NIH HHS/United States 263 MD 821336/MD/NIMHD NIH HHS/United States HL54512/HL/NHLBI NIH 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N01-HC-55021/HC/NHLBI NIH HHS/United States R01HL060894/HL/NHLBI NIH HHS/United States N01-HC-95165/HC/NHLBI NIH HHS/United States G0700931/MRC_/Medical Research Council/United Kingdom MC_PC_U127527180/MRC_/Medical Research Council/United Kingdom G0902037/MRC_/Medical Research Council/United Kingdom HL098283/HL/NHLBI NIH HHS/United States ES10126/ES/NIEHS NIH HHS/United States R01HL071252/HL/NHLBI NIH HHS/United States U01 HL054471/HL/NHLBI NIH HHS/United States N01-HC-85086/HC/NHLBI NIH HHS/United States TW05596/TW/FIC NIH HHS/United States R01 HL105756/HL/NHLBI NIH HHS/United States U01HG004402/HG/NHGRI NIH HHS/United States R01HL071205/HL/NHLBI NIH HHS/United States U01HG004422/HG/NHGRI NIH HHS/United States MC_U123092723/MRC_/Medical Research Council/United Kingdom HG003054/HG/NHGRI NIH HHS/United States HL084729/HL/NHLBI NIH HHS/United States DK56350/DK/NIDDK NIH HHS/United States N01-HC-85082/HC/NHLBI NIH HHS/United States RR20649/RR/NCRR NIH HHS/United States 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