Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
第一作者:
Goedele,Wallays
第一单位:
Vesalius Research Center, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
作者:
医学主题词
动物(Animals);精氨酸(Arginine);脑(Brain);CADASIL(CADASIL);毛细血管(Capillaries);胱氨酸(Cystine);疾病模型, 动物(Disease Models, Animal);生育力(Fertility);基因敲入技术(Gene Knock-In Techniques);小鼠(Mice);运动活动(Motor Activity);肌, 平滑, 血管(Muscle, Smooth, Vascular);突变(Mutation);受体, Notch(Receptors, Notch)
DOI
10.1161/ATVBAHA.111.237859
PMID
21940951
发布时间
2016-11-25
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