Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice.
第一作者:
Shailaja,Hegde
第一单位:
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, 16802, USA.
作者:
主题词
动物(Animals);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);细胞周期蛋白质类(Cell Cycle Proteins);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);环戊烷类(Cyclopentanes);DNA结合蛋白质类(DNA-Binding Proteins);剂量效应关系, 药物(Dose-Response Relationship, Drug);脂肪酸类, ω3(Fatty Acids, Omega-3);白血病(Leukemia);白血病, 幼红细胞, 急性(Leukemia, Erythroblastic, Acute);白血病, 髓系, 慢性, BCR-ABL阳性(Leukemia, Myelogenous, Chronic, BCR-ABL Positive);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);分子结构(Molecular Structure);肿瘤干细胞(Neoplastic Stem Cells);前列腺素(Prostaglandins);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);脾大(Splenomegaly);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1182/blood-2010-11-317750
PMID
21967980
发布时间
2021-12-03
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Blood
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