Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.
作者:
主题词
卡配因(Calpain);细胞膜(Cell Membrane);内皮细胞(Endothelial Cells);内皮, 血管(Endothelium, Vascular);细胞外基质(Extracellular Matrix);基因沉默(Gene Silencing);人类(Humans);溶血磷脂素类(Lysophospholipids);基质金属蛋白酶14(Matrix Metalloproteinase 14);显微镜检查, 荧光(Microscopy, Fluorescence);新生血管化, 病理性(Neovascularization, Pathologic);抗剪切强度(Shear Strength);鞘氨醇(Sphingosine);应力, 物理(Stress, Mechanical);亚细胞部分(Subcellular Fractions);脐静脉(Umbilical Veins)
DOI
10.1074/jbc.M111.290841
PMID
22002053
发布时间
2024-03-18
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The Journal of biological chemistry
42017-42026页
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